The media is abuzz: Louisville's 21C is the hottest thing this side of the Mississippi. The newly-opened boutique hotel-- listed on the National Register of Historic Places-- is part of what the New York Times calls Louisville's "downtown renaissance." The 90 rooms (including six premier suites) are elegantly decorated and are equipped with state-of-the-art technology, including 42' flat-screen televisions and WiFi. But this masterpiece is not merely a luxury boutique hotel; 21C is also a museum of contemporary art, housing pieces from the owner's mind-blowing $10 million art collection. (Philanthropists Steve Wilson and Laura Brown, a husband and wife team, are the co-developers.)